Cervical Cancer

HIV genome

Virion

HPV life cycle

HPV infection

Cancers and HPV

HPV cancers

Cervical cancer

HPV carcinogenesis

Cellular proteins

HPV pathways

HPV infection time line

HPV infection

Pap screening

Primary prevention

Virus like particles

Three vaccines

Timeline of HPV Association

Precursor Lesions

Efficacy of HPV Vaccine

Gardasil-9

Clinical Trial Evidence

What the HPV Vaccines Don’t Do They don’t prevent infection or disease caused by

most of the other HPV types that cause 30% of

cervical cancer not caused by HPV16/18.

They don’t induce regression of established HPV

infections or prevent progression of HPV-induced

lesions.

7 Years after vaccination

Protection from Initial Infection

HPC vaccine

Safety record

Vaccine effectiveness

Vaccination

CIN1 reduction

Effectiveness

Cervical cancer prevention

Worldwide HPV vaccine

uptake

US girls vaccination rate

Increasing Uptake, Particularly

in Low Resource Settings

One dose efficacy of Cervarix

Cervarix after 4 years

One dose clinical trials

Single dose efficacy trial

HPV vaccines

Immune mediators of protection

Antibody responses to VLPs

Persistence of antibodies

B cells recognize dense

repetitive protein arrays

Repetitive antigen display

Virus like particles

Durable serum Abs

Antibody response

HPV achilles heal

Cervix Ab response

Murine model

Basement membrane

Antibody titers and protection

Passive transfer

Keratinocyte transfer

Gardasil sera protection

Conclusions

Collaborators