Post on 13-Dec-2015
Cell-mediated immune response
Activation of T lymphocytes by intracellular microorganisms
Phases of T cell responseBiochemical pathways of T cell activation
Functional responses of T lymphocytes to antigens and costimulation
TCR
TCR complex
Molecules involved in T cell activation
Costimulators
Requirement for two signals in T cell activation
Molecules involved in T cell activation
Adhesion molecule
Coreceptor
Molecules involved in T cell activation
Accessory molecules
Molecules involved in T cell activation
Immunological synapse
Biochemical pathways ofT cell activation
Clustering of two or more
TCRs
Functional responses of T lymphocytes to antigens
and costimulation
Clonal expansion of T-limphocytes
Treg
Naivna CD4+TNaïveCD4+T
Th1
Th2
TGF-
TGF-+IL-6
IL-4
IL-12+IL-18
IFN-
IL-23…Th17
Diferentiation od CD4+ T-limphocytes
Th17
Th1
Treg
Naivna CD4+T
Th2
TGF-
TGF-+IL-6
IL-4
IL-12+IL-18
IL-23…
T-bet
GATA-3
RORt
FoxP3
IFN-
Th17
Diferentiation od CD4+ T-limphocytes
NaïveCD4+T
Diferentiation of naive
CD4+ T-cells
Diferentiation od CD8+ T-limphocytes
CD3 complex and chainsj.Main transcription factors in T cell activation are10.
T cell is not activatedi.Cytokine that is crucial for TH1 differentiation is9.
IL-12h.Activation of naive T-cells requires8.
CD3, CD4, CD8, CD28 and adhesion molecules
g.Adhesion molecules7.
CD28 and B7 moleculesf.If APC does not express costimulatory molecules
6.
NFAT, NF-B and AP1e.
T cell growth factor is 5.
two signalsd.
Costimulatory signals for T cell activation are provided by
4.
and chains of TCRc.
Accesory molecules involved in T cell activation are
3.
stabilize binding of T-cells to APC
b.
Signal transduction in T cells is mediated by2.
IL-2a.Recognition of antigen by T cells is mediated by1.
10.____9.____8.____7.____6.____5.____4.____3.____2.____1.____c j g f a i b d h e