Post on 01-Sep-2018
The world leader in serving science
Building on Our Industry Leadership
Marc N. CasperChief Operating Officer
Ian D. Jardine, PhDVice President, Global R&D
Pittcon 2009 Press ConferenceMarch 9, 2009
2
The World Leader in Serving Science
We are the leading provider of analytical instruments, equipment, reagents and consumables, software and services
for research, analysis, discovery and diagnostics.
Size and Scale
$10.5 billion in revenues34,000+ employees in 40 countriesServing 350,000 customers in 150 countriesFortune 300 company
Unmatched Capabilities
Complete portfolioWorld-class technologiesCommercial and service strength
Leading Brands
3
A Mission We are Proud of
We enable our customers to make the world healthier, cleaner and safer
CleanerHealthier Safer
4
Our Strengths
Global industry leadership
Key competitive advantages• Broad portfolio• Diverse customer base• Global reach• Strong balance sheet
Excellent track record of financial performance
A partner you can count on
Ability to continuously invest in growth opportunities• Developing innovative products
• Invested $250 million in R&D in 2008• Strengthening commercial capabilities
• Extending our channel reach• Expanding in growing markets
• Focus on China and India
5
A Compelling Value Proposition
TargetedInnovation
Extended BusinessPartner
Scientific Productivity
We deliver unmatched scientific productivity through our innovative technologies, services and systems.
6
Thermo Scientific: New Products for Today’s Demands
Differentiated in performance and productivity
Voice of Customer
Ease of useAdvanced technologies for non-experts
Greater efficiency and productivity
Integrated workflowsData management
Better analytical performance
Speed and sensitivityPrecise quantitation
Broad applicationsLaboratoryIndustrial and field
SustainabilityEnergy efficiencyReduced solvent usage
7
Fisher Scientific: One Source, Infinite Solutions
Providing customers with a growing portfolio of convenient sourcing and service options
8
Helping our Customers Achieve their Goals
Targeted Innovation
Laboratory Productivity
Business Partner
Pharmaceutical Customer
Consolidated orderingE-commerce platformThird-party sourcingOutsourced services and asset management
Scientific collaborationMethods developmentApplication-based workflowsData management
Equipment standardizationStandard operating procedures and validationGlobal logistics network
9
Expanding our Capabilities with Strategic Acquisitions
Open Biosystems: RNAiAffinity Bioreagents: Antibodies
Chemito Technologies:Routine analytical instruments
FiberLite: Carbon fiber centrifuge rotors
Hucoa Erloss, Afora, Bonsai: Extends European channels
Consumables and Reagents
EquipmentInstrumentation
Customer Channels
10
The World Leader in Serving Science
11
Pittcon 2009: New Products for Key Applications
Data Interpretation
Sample Analysis
Sample Preparation
12
Pittcon 2009: New Products for Sample Preparation
Sample Preparation
Sample Analysis
Data Interpretation
13
Pittcon 2009: New Products for Sample Preparation
Protein Catalogs
Electrodes
Meters
siRNA, shRNA, miRNABioreagents
Hamilton Infinity Fume Hood
Hamilton Distinction II Green Lab Furniture
14
Pittcon 2009: New Products for Sample Analysis
Sample Analysis
Data Interpretation
Sample Preparation
15
New Thermo Scientific Products for Sample Analysis
Accela Exactive™ LCMS
TSQ Vantage™
Niton XRF GOLDD™Titan 4000™
NSX Analyzer
Basic Research
Drug Discovery & Development
Environmental &Food Screening
Industrial & Product Testing
Petroleum & Chemical
Arena™
Chemistry Analyzer
A range of innovations, from research to routine testing
NanoDrop™
2000/2000cUV/Vis
R
Transcend TLX™ Access Max™
LCMS
16
Quick, easy, accurate UV-Vis analysisLow or no sample prep, reduced solventsMore sensitivity
Thermo Scientific NanoDropCustomer Needs:
Our Response:Unique “all-in-one” Spectrophotometer
Ideal for DNA, RNA, proteins, cell culturesPatent-pending combination of micro-volume pedestal and built-in cuvette capability200X concentration vs. conventional specsBroad wavelength rangeKinetics capability
Basic Research
Revolutionary New Micro UV-Vis Capability
Dramatic advances in UV-Vis performance
17
Accurate: absorbance accuracy and precision 2% and .002
Advanced: custom methods capability yes
Versatile: number of path lengths 7
Compact: footprint (cm) 14 x 20
Fast: measurement time (secs) <3 (cuvette)
Fast: measurement time (secs) <5 (pedestal)
Broad: wavelength range (nm) 190 - 840
Small: minimum sample size (µl) 0.5
Broad: concentration range (ng/µl) 0.4 – 15,000 ng/ul (dsDNA)
Thermo Scientific NanoDrop 2000c
Leading-Edge Performance
Key Specifications
18
Intuitive, Clear, Easy-to-Use Software
19
Greater sensitivity (S/N) for ultralow-level quantitationPrecision and reproducibilityMultiple analytes per run
Unmatched signal-to-noise performance exceeds customer expectations
Highest Triple Quad Sensitivity
Customer Needs:
Our Response:10X more sensitivity than any other triple quad
1,000 SRMs per second and 3,000 timed SRMs per LC run
Full peptide, protein quantitation
TSQ series 2.0.0 software
Thermo Scientific TSQ Vantage Mass Spec
Drug Discovery & Development
Hesi II probe
New sweep
cap
Patented S-lens
20
TSQ Vantage Beats Existing SystemsSample Name: "Std 0.01" Sample ID: "" File: "08305rlc39a PPT Evap 8Mar08 4.wiff"Peak Name: "Dextromethorphan-d3" Mass(es): "275.2/171.2 amu"Comment: "" Annotation: ""
Sample Index: 31 Sample Type: Standard Concentration: 0.0100 Calculated Conc: 0.0109 Acq. Date: 3/9/2008 Acq. Time: 2:11:48 PM Modified: No Proc. Algorithm: IntelliQuan - MQII Noise Percentage: 93 Base. Sub. Window: 1.00 minPeak-Split. Factor: 2 Report Largest Peak: No Min. Peak Height: 200.00 cpsMin. Peak Width: 4.00 secSmoothing Width: 3 pointsRT Window: 30.0 secExpected RT: 2.72 minUse Relative RT: No Int. Type: Base To Base Retention Time: 2.69 minArea: 1892.34 countsHeight: 5.72e+002 cpsStart Time: 2.63 minEnd Time: 2.74 min
1.1 1.2 1.3 1.4 1.5 1.6 1.7 1.8 1.9 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 2.9 3.0 3.1 3.2 3.3 3.4 3.5 3.6Time, min
0
20
40
60
80
100
120
140
160
180
200
220
240
260
280
300
320
340
360
380
400
420
440
460
480
500
520
540
560
580
600
620
640
660
680
700
720
740
Inte
nsity
, cps
2.68
2.59
3.23
2.82
3.072.78
3.412.85 3.132.95 3.582.40 3.34
RT: 0.98 - 3.96
1.0 1.5 2.0 2.5 3.0 3.5Time (min)
0
5
10
15
20
25
30
35
40
45
50
55
60
65
70
75
80
85
90
95
100
Rel
ativ
e A
bund
ance
RT: 3.04 NL: 1.35E4TIC F: + c ESI SRM ms2 275.180 [171.049-171.051] MS ICIS tt-test_mix_124competitor
TSQ Vantage
>10X LOQ better than
competitor’sbest efforts
Unsurpassed triple quad performance
Dextromethorphan-d3In Rat Plasma
(LLOQ at 0.01 ng/mL)
21
Environmental & Food Screening
Quantum Access MAX™
Advanced screening for routine applicationsHigher sensitivity and throughputStreamlined method development
High Performance for Routine Applications
The value choice for routine food safety, pharma, environmental and clinical applications
Thermo Scientific Workflow SolutionCustomer Needs:
Accela UHPLC™ TraceFinder™ Software
Simultaneous quantitation and structural confirmationFast +/- switching for high-speed multi-component trace analysis3000 timed SRMs per LC runNew TraceFinder software
Our Response:
22
Accela-Access Max Performance in Pesticide Screening
Complex multi-residue pesticide analysis (10 ppt) in <3 minutes
Carpropamine
Daimuron
Tricyclazole
Carbaryl
Carbofuran
Siduron
Diuron
Time (minutes)
23
End-to-End Workflow for Multiplexing LC/MS/MS
In-line sample extractionEnd-to-end workflow analysis
High-throughput benchmark for clinical and drug analysis
Customer Needs:Thermo Scientific Workflow Solution
Our Response:Doubles sample analysis throughputIncreases detection limits
New high performance ultralow dead volume LC pumps
Fully integrated software for multiplexed LC-MS
Transcend TLX™ Accela UHPLC™ TSQ Vantage™
Drug Discovery & Development
24
Environmental & Food Screening
Full scan MS with HCD scanningWalk-up compound identification
• Pesticides, metabolites, tox screeningNew quantitation capabilitiesPowerful Pathfinder™ software
A Revolution in LC-MS
Cost effective target ID and compound identificationHigher throughput analysis with advanced mass accuracyEasy-to-use workflow enabler and productivity platform
Speed, spectra, ultrahigh resolution, superb accurate mass, and precise quantitation all in an affordable bench-top system
Accela UHPLC™
Customer Needs:Thermo Scientific Exactive
Our Response:
25
1.20298.2741C18H35NO2Spiroxamine
1.70297.0556C14H14Cl2N2OImazalil
0.20296.1161C14H18ClN3O2Triadimenol
2.00295.0222C10H15O4PS2Fenthion-sulfoxide
1.40294.1368C15H20ClN3OPaclobutrazol
0.30294.1004C14H16ClN3O2Triadimefon
0.70253.0309C10H9ClN4SThiacloprid
1.20249.0192C9H10Cl2N2O2Linuron
0.90241.0963C9H13ClN6Cyanazine
0.10240.0786C12H14ClNO2Clomazone
6.50239.1503C11H18N4O2Pirimicarb
1.20237.1234C12H16N2O3Carbetamide
2.00233.0243C9H10Cl2N2ODiuron
2.50216.1011C8H14ClN5Atrazine
2.00215.0961C8H14N4OSMetribuzin
1.20213.0789C10H13ClN2OChlortoluron
1.10210.1125C11H15NO3Propoxur
Error [ppm] [M+H]Elemental CompositionComponent
The Value of Reproducible High Mass Accuracy
Fast chromatography (<15mins)Exactive running at 15,000 resolution
All molecular weight masses within ± 2.5 ppm except…
Total of about 110 pesticides(each ~ 250 ug/L)
in very complex horse feed matrix
26
1.20298.2741C18H35NO2Spiroxamine
1.70297.0556C14H14Cl2N2OImazalil
0.20296.1161C14H18ClN3O2Triadimenol
2.00295.0222C10H15O4PS2Fenthion-sulfoxide
1.40294.1368C15H20ClN3OPaclobutrazol
0.30294.1004C14H16ClN3O2Triadimefon
0.70253.0309C10H9ClN4SThiacloprid
1.20249.0192C9H10Cl2N2O2Linuron
0.90241.0963C9H13ClN6Cyanazine
0.10240.0786C12H14ClNO2Clomazone
6.50239.1503C11H18N4O2Pirimicarb1.20237.1234C12H16N2O3Carbetamide
2.00233.0243C9H10Cl2N2ODiuron
2.50216.1011C8H14ClN5Atrazine
2.00215.0961C8H14N4OSMetribuzin
1.20213.0789C10H13ClN2OChlortoluron
1.10210.1125C11H15NO3Propoxur
Error [ppm] [M+H]Elemental CompositionComponent
The Value of Reproducible High Mass Accuracy
Unusually high error of 6.5 ppmRe-analyze @ higher resolution of 80,000
Only Orbitrap technology allows this level of confidence
Total of about 110 pesticides(each ~ 250 ug/L)
in very complex horse feed matrix
Pirimicarb
6.50
The world leader in serving science
28
The Value of High Mass Accuracy and Ultrahigh Resolution
The Case for ExactiveA mixture of >100 pesticides, mycotoxins and veterinary drugs at different concentration levels in horse feed matrix analyzed at two resolution settings utilizing full scan accurate mass measurements (+/- 2ppm)
100k
10K
0 20 40 60 80 100
250
50
10
% Detected
Det
ecte
d co
mpo
unds
ppm
45%
10K resolution can’t detect known chemicals
Vastly superior analytical results with Orbitrap performance
99%
100%
93%
32%
11%
250
10
The power of 100K resolution
29
The Value of High Mass Accuracy and Ultrahigh Resolution – Quantitation
Concentration ranging from
0.2 ppb to 500 ppb
Dextrorphanwith internal
standard0.5 - 500 pg on-column
Concentration ranging from
0.2 ppb to 500 ppb
Dextrorphanwith internal
standard0.5 - 500 pg on-column
Lowest Data point
profile
+/- 5 ppm
30
Drug Discovery & Development
Enabling the right workflow for the right userDeveloped methods significantly streamline analysis Links into other software:
• Thermo Scientific ToxID • Thermo Scientific Xcalibur
New Pathfinder Screening Software for Exactive
Pathfinder leverages full instrument capabilities
Thermo Scientific Pathfinder
Walk-up user Experienced user
Reports
31
Orbitrap Technology for Routine Screening Applications
Exactive™ will displace TOFs and QTOFs!
Thermo Scientific Exactive
32
Easy sample introductionSimple operationIncreased analysis speed and sensitivity
Total nitrogen and total sulfur (TN/TS) analysis in <2 minutesUp to 60% reduction in bench spaceNew nebulizing injection technique with high efficiency folded combustion tubeNSX visual software
Petroleum & Chemical
Thermo Scientific TITAN 4000 NSX Analyzer
New capability for QC with increased productivity and lower operating costs for petrochemical and refinery industries
Customer Needs:
Our Response:
Superior Total NSX Analysis in a Small Footprint
EST AnalyticalBooth 1816
33
Next-Generation Portable XRF Elemental Analysis
Breakthrough lab-quality performance in a handheld detector
Other Technology
Smaller AreaDetector Large Area
Detector
Thermo ScientificNiton XL3t GOLDD
Samples
10x faster than conventional detectors 3x more precise than traditional silicon drift detectorsProprietary GOLDDTM Large Area Drift Detector Light element detection without helium or vacuum purging
Customer Needs:Speed and sensitivityPortable and field rugged Identify multiple elementsReal time data and simple software interface
Industrial & Product Testing
Our Response:
Thermo Scientific Niton XL3t GOLDD
34
“Clinical Chemistry” Analyzer for Non-clinical Labs
Fast and efficient analysis in an advanced all-in-one system
• Colorimetric and enzymatic applications• 45 reagent positions• Wavelength range 340 to 880 nm• Automatic barcode ID
Accurate QC and analysis for pharma, agricultural, food
• Example: Asparagine + glucose = potentialacrylamide formation
Sample throughput up to 600 tests per hour
Customer Needs:
Industrial & Product Testing
Our Response:
Easy and rapid automated methodsWalk-away analysisSingle system for multiple applications
Thermo Scientific Arena Analyzer
35
Pittcon 2009: New Data Interpretation Solutions
Data Interpretation
Sample Analysis
Sample Preparation
36
Pittcon 2009: New Data Interpretation Solutions
OMNIC Specta on Raman
Pathfinder TraceFinder
Enterprise Insights
Connects
37
0001110101010010010110101001010100101010100011010010101011010101010101010101010101010110101010101010
Maximize customer ROI from previous software investments
Pittcon 2009: New Data Interpretation Solutions
38
A Mission We are Proud of
We enable our customers to make the world healthier, cleaner and safer
CleanerHealthier Safer
Pharma & BiotechQuantitationSpeedSelectivityData management
Environmental &Industrial
PortabilitySpeedSensitivityRobustness
Food SafetyScreeningConfirmationThroughputEase of use
39
See it All!
Mass Spectrometryand Chromatography
Water Purification
Water Analysis Instruments
Elemental AnalysisUV-Visibleand Fluorescence
Particle Technology
LIMS, COS andSpectroscopySoftware
ChromatographyConsumables
Mass Spectrometryand Chromatography
HandheldXRF AnalyzersElemental Analysis
Molecular Spectroscopy
Laboratory Furnitureand Fume Hoods
Information
Discrete PhotometricAnalyzers
TRAM
Blue Crew
Fisherbrand and Fisher Scientific products Nucleus
Life Science
Chemicals
Chromatography
Spectroscopy
SamplePreparation
Micro/AnalyticalTechnologies
Fisherbrand andFisher Scientific products
40
Your Passport to Scientific Innovation
Visit Thermo Scientific Booth 1432
Mass Spectrometryand Chromatography
Water Purification
Water Analysis Instruments
Elemental AnalysisUV-Visibleand Fluorescence
Particle Technology
LIMS, COS andSpectroscopySoftware
ChromatographyConsumables
Mass Spectrometryand Chromatography
HandheldXRF AnalyzersElemental Analysis
Molecular Spectroscopy
Laboratory Furnitureand Fume Hoods
Information
Discrete PhotometricAnalyzers