Beginning of the ChapterNutriMe Complete: Personalized

Micronutrients Based on Your Genetic Profile

6

Genetically Personalized Dietary Supplements

Bone healthOsteoporosis (calcium, vitamin D, magnesium)

Eye healthMacular degeneration (antioxidants)

Heart healthCholesterol (Omega3)Homocysteine (folic acid, vitamin B)

Food intolerancesLactose intolerance (calcium)Gluten intolerance (multivitamin)

Joint healthRheumatoid Arthritis (Omega3)

Metabolism healthHemochromatosis (iron)

Mental healthAlzheimer's disease (antioxidants)

DetoxificationHeavy metals (calcium, selenium, iron)

MICRONUTRIENTSGenetics allows us to recognize the

micronutrient requirements

MICRONUTRIENTS

An example of a micronutrient needed in higher doses

OXIDATIVE STRESS

GPX1 – A Selenoprotein which neutralizes free radicals

GPX1

GPX1

Free Radical

GPX1

GPX1Selenium

OXIDATIVE STRESS

Free Radical

GPX1 – A Selenoprotein which neutralizes free radicals

GPX1

GPX1

SeleniumFree Radical

OXIDATIVE STRESS

GPX1 – A Selenoprotein which neutralizes free radicals

GPX1

GPX1

OXIDATIVE STRESS

Selenium

GPX1 – A Selenoprotein which neutralizes free radicals

GPX1

GPX1

Neutralized

OXIDATIVE STRESS

Selenium

GPX1 – A Selenoprotein which neutralizes free radicals

Selenium deficiency30% activity

OXIDATIVE STRESS

GPX1 – A Selenoprotein which neutralizes free radicals

More selenium 70% activity

OXIDATIVER STRESSSelenium deficiency and GPX1 activity

Selenium deficiency30% activity

GPX1

GPX1

OXIDATIVE STRESSGenetic variations reduce activity

FreeRadical

GPX1

GPX1

Selenium

OXIDATIVE STRESS

Free Radical

Genetic variations reduce activity

GPX1

GPX1

weaker binding(e.g., 50% less)

OXIDATIVE STRESS

Selenium

Genetic variations reduce activity

Normal selenium35% activity

OXIDATIVE STRESSGenetic variations reduce activity

OXIDATIVE STRESS

Normal selenium35% activity

More selenium60% activity

Genetic variations reduce activity

OXIDATIVE STRESSThe GPX1 Gene

GPX1

55 µg / day

OXIDATIVE STRESSDosage Based on Genetics

GPX1GPX1

96 µg / Day

OXIDATIVE STRESSDosage Based on Genetics

55 µg / Day

OXIDATIVE STRESS

An example of how a micronutrient has no effect

Coenzyme Q10 must be activated

Q10 Q10 – No effect

OXIDATIVE STRESS

Q10

NQO1

Q10

UBIUbiquinolantioxidant protection

Coenzyme Q10 must be activated

Q10 – No effect

OXIDATIVE STRESS

Q10

NQO1

Q10

UBI Free Radical

UBIUbiquinol

antioxidant protection

Q10 – No effect

OXIDATIVE STRESS

Coenzyme Q10 must be activated

NQO1 Activates the Q10 Coenzyme

OXIDATIVE STRESS

Q10

NQO1

Q10

Coenzyme Q10 Must Be Activated

Q10 – No effect

OXIDATIVE STRESS

Q10

NQO1

Free Radicals

Q10

Coenzyme Q10 Must Be Activated

Q10 – No effect

OXIDATIVE STRESS

Q10

NQO1

Q10

UBI

UBI

UBI

UBI UBI

UBIUBI

Free Radicals

Coenzyme Q10 Must Be Activated

Q10 – No effect

OXIDATIVE STRESS

Q10

NQO1

Q10

C

E

ALA

CE

E ALAC

ALA

E

Free Radicals

Coenzyme Q10 Must Be Activated

Q10 – No effect

OXIDATIVE STRESS

NQO1

Q10

Coenzyme Q10 Must Be Activated

OXIDATIVE STRESS

NQO1NQO1

Q10Q10 UBIC

E

ALA

Coenzyme Q10 Must Be Activated

OXIDATIVE STRESS

MIKRONÄHRSTOFFE

Various factors which affect the calcium requirement

Factor 1) Lactose intolerance

MICRONUTRIENTS

Lactose Intolerance and Calcium

Lactase geneAge++

LACTOSE TOLERANT

= 600mg calcium

through diet

Calcium RDA800mg/day

Ca

Ca 200mg/day

= 800mg Calcium/day

MICRONUTRIENTS

Lactose Intolerance and Calcium

Lactase geneAge++

LACTOSE TOLERANT

= 600mg Calcium

through diet

Lactase geneAge++

LACTOSE INTOLERANT

= 30mg Calcium

through dietCalcium RDA800mg/day

Ca

Ca 200mg/day

= 800mg Calcium/day

MICRONUTRIENTS

Lactose Intolerance and Calcium

Lactase geneAge++

LACTOSE TOLERANT

= 600mg Calcium

through diet

Ca

Ca Ca

CaCaCa

Ca

770mg/day

Lactase geneAge++

LACTOSE INTOLERANT

= 30mg Calcium

through dietCalcium RDA800mg/day

Ca

Ca 200mg/day

= 800mg Calcium/day

MICRONUTRIENTS

Lactose Intolerance and Calcium

Lactase geneAlter++

LACTOSE TOLERANT

= 600mg Calcium

through diet

MICRONUTRIENTS

Various factors which affect the calcium requirement

Factor 1) Lactose intoleranceFactor 2) Osteoporosis

OSTEOPOROSIS

Bone Density and Age

Osteoporosis

Osteopenia

Bone

den

sity

Age (years)10 20 30 40 50 60 70

Normal: bone density increases until 30 years of age and then gradually decreases

Gene variations:The bone density decreasesfaster

OSTEOPOROSIS

Bone Density and Age

Osteoporosis

Osteopenia

Bone

den

sity

Age(years)10 20 30 40 50 60 70

PREVENTION

OSTEOPOROSIS

What Calcium Dosage is Optimal?

0 mg

1500 mg

RDA according to EFSA800 mg

0 mg

1500 mg

Effective, according to studies

OSTEOPOROSIS

What Calcium Dosage is Optimal?

RDA according to EFSA800 mg

1200 mg

0 mg

1500 mg

800 mg

1200 mg

800mgNormal (low) risk

Effective, according to studies

OSTEOPOROSIS

What Calcium Dosage is Optimal?

RDA according to EFSA

0 mg

1500 mg

1200mgMaximum risk

800 mg

1200 mg

800mgNormal (low) risk

Effective, according to studies

OSTEOPOROSIS

What Calcium Dosage is Optimal?

RDA according to EFSA

MICRONUTRIENTS

Various factors which affect the calcium requirement

Factor 1) Lactose intoleranceFactor 2) OsteoporosisFactor 3) Detoxification of heavy metals

Detoxification of heavy metals

MICRONUTRIENTS

Is the RDA sufficient??

PHASE 2 DETOXIFICATION

Enzymes remove heavy metals from the body

LEAD

Enzymatic modification

Neutralized

GSTM1

GSTT1

GSTP1

Removed by the kidneys

GSTM1

GSTT1

GSTP1

Poisoning, cancer

LEAD

PHASE 2 DETOXIFICATIONGenetic variation leads to less

protection against lead

GSTM1

GSTT1

GSTP1

Calcium binds lead

Ca

Ca

Ca

Calcium supplement binds lead

Removed by kidneys

LEAD

PHASE 2 DETOXIFICATIONGenetic variation leads to less

protection against lead

MICRONUTRIENTS

Various Factors Which Affect the Calcium Intake

Factor 1) Lactose intoleranceFactor 2) OsteoporosisFactor 3) Detoxification of heavy metals

To summarize: what is the right dosage?

CALCIUM

What affects the optimal calcium intake?

Lactose intolerant

Osteoporosis risk

Limited detoxification

RecommendedRDA

800 mg

No+0 mg

Yes+150 mg

No+0 mg

No+0 mg

Yes+100 mg

=800mg

Yes+150 mg

Yes+150 mg

Yes+150 mg

Yes+100 mg

NO+0 mg

No+0 mg

No+0 mg

=1050mg

=950mg

=1200mg

MICRONUTRIENTS

An example of how a micronutrient can have different

effects

OMEGA 3

An observations often made by doctors

Person 1 with low HDL cholesterol

The doctor recommends omega 3 supplements

HDL cholesterol improves

Person 2 with low HDL cholesterol

The doctor recommends omega 3 supplements

HDL cholesterol is becoming worse

What is the difference?

APOA1 (A/A) APOA1 (G/G)

OMEGA 3

An Observations Often Made by Doctors

Person 1 with low HDL cholesterol

The doctor recommends omega 3 supplements

HDL cholesterol improves

Person 2 with low HDL cholesterolPerson 1 with low HDL cholesterol

The doctor recommends omega 3 supplementsThe doctor recommends omega 3 supplements

APOA1 (A/A) APOA1 (G/G)

The doctor recommends phytosterols

Various micronutrients achieve similar results

HDL cholesterol improvesHDL cholesterol improves

OMEGA 3

An Observations Often Made by Doctors

RDA: 250 mg

Based on studies: 1000-2900mg

OMEGA 3

What dosage is optimal?

0 mg

3000 mg

250mg

1000mg

1500mg

2900mg Study 3

Study 1

Study 2

RDA according to EFSADose recommended for the

general population = RDA

Effective dose, according to studies

Daily dose

OMEGA 3

What dosage is optimal?

CETP

APOA5

HDL Cholesterol

OK

CHOLESTEROL

Cholesterol is affected by genes

Genes that influence HDL

CETP

APOA5APOA1

250mgOMEGA3

HDL Cholesterol

OK

CHOLESTEROL

Cholesterol is affected by genes

Genes that influence HDL

APOA1250mgPhytoster.

CETP

APOA5APOA1

250mgOMEGA3

HDL Cholesterol

OK

CHOLESTEROL

Cholesterol is affected by genes

Genes that influence HDL

CETP

APOA5

HDL Cholesterol

too low

APOA1250mgPhytoster.

CETP

APOA5APOA1

250mgOMEGA3

HDL Cholesterol

OK

CHOLESTEROL

Cholesterol is affected by genes

Genes that influence HDL

APOA1 1500mgOMEGA3

CETP

APOA5

HDL Cholesterol

too low

APOA1250mgPhytoster.

CETP

APOA5APOA1

250mgOMEGA3

HDL Cholesterol

OK

CHOLESTEROL

Cholesterol is affected by genes

Genes that influence HDL

APOA11500mgPhytoster.

APOA1 1500mgOMEGA3

CETP

APOA5

HDL Cholesterol

too low

APOA1250mgPhytoster.

CETP

APOA5APOA1

250mgOMEGA3

HDL Cholesterol

OK

Genes that influence HDL

CHOLESTEROL

Cholesterol is affected by genes

SUMMARY

Genes Influence the Micronutrient requirement

Genes influence the effect of MN’s

Genes influence the necessary dosage

By analysing 50+ genes, we can individually dose 20 + micronutrients

For 50 genes, there are 717 000 000 000 000 000 000 000 possible genetic profiles

Each nutrient mixture is unique

MICRONUTRIENTS

How can you follow such a detailed requirement?

How Can You Follow Such an Extensive Recommendation?

Standard products?

The dosages are always too high or too low

Very expensive

Easy to produceOptimal absorption

MICRONUTRIENTS

Microtransporter technology

Personalized mixed capsules?

Vitamin C mix50% w/w

Vitamin A mix4% w/w

Zinc mix11% w/w

Mixture for one genetic

profile

38g6g 22g

Instructions: ingest 8g/day

Zinc mix

Vitamin A mix

Vitamin C mix

Molecule of fillerMolecule of Vitamin CMolecule of Vitamin AMolecule of Zinc

Amounts differ depending on genetic profile

Various micro transporters are mixed in different ratios to produce an unique combination

How Can You Follow Such an Extensive Recommendation?

MICRONUTRIENTS

A spoon of microtransporters

MICRONUTRIENTS

MICRONUTRIENTS

Slow Release – absorbed by the body over a period of 8 hours

Absorption-inhibiting micronutrients are released at different locations in the intestine

The pellets can be swallowed or mixed with yogurt

A spoon of microtransporters

End of the ChapterNutriMe Complete: Personalized

micronutrients based on your genetic profile

6