4th & Aspen Life Sciences Consulting

Supercharging R&D innovation .

Our mission

© 2014 4th & Aspen LLC

We help companies in the discovery and development of innovative biotools & biotherapeutics.

2

Our Founders

B.S., PhD Univ. of Minnesota, Minneapolis

Postdoctoral research DNAX Research Institute

MBA Presidio Graduate School

Senior Scientist Abgenix, Inc.

Senior Scientist Entelos, Inc.

VP, Marketing; VP, R&D NeuroScience, Inc.

Scientific Review Officer SRA International

© 2014 4th & Aspen LLC

3

B.S. PhD Stanford UC-Berkeley

Postdoctoral research UCSF

Senior Scientist DNAX Research Institute

Senior Scientist Genentech (Roche)

Visiting Scientist Stanford University

Chief Scientific Officer NeuroScience Inc.

Chief Technical Officer R&D Systems/Techne

S i r i d K e l l e r m a n n , P r e s i d e n t F e r n a n d o B a z a n , P r i n c i p a l

Why work with 4th & Aspen?

© 2014 4th & Aspen LLC

Our key strengths:

✔  A deep understanding of how biological systems work

✔  A track record of elucidating novel target mechanisms - repeatedly breaking new ground in drug discovery (www.4thandaspen.com/our-expertise/cases)

✔  The ability to work across scientific fields and catalyze interdisciplinary collaborations that are often lacking, but critical to innovation

✔  Industry-proven decision analysis approach to guide target selection and R&D portfolio strategies

✔  Experience in biopharma market research, competitive analysis, & commercial assessment

4

We bring 3 decades of leadership in target discovery and preclinical R&D

The image cannot be displayed. Your computer may not have enough memory to open the image, or the image may have been corrupted. Restart your computer, and then open the file again. If the red x still appears, you may have to delete the image and then insert it again.

© 2014 4th & Aspen LLC

5

We bring 3 decades of leadership in target discovery and preclinical R&D

© 2014 4th & Aspen LLC

6

Disease-associated target discovery

Protein structure/function

Cellular & in vivo validation

R&D portfolio evaluation

Biomarker evaluation & clinical trial optimization

Market & commercial assessment Protein signaling/

relationships

Sirid Kellermann: Strategic project & relationship management successes

© 2014 4th & Aspen LLC

•  Strong expertise in immuno-inflammatory disorders

•  >20 R&D projects executed with global biopharma clients

•  R&D and Marketing leadership •  Training in strategic decision &

risk management

7

130 publications

>25,000 citations

>35 patents

Fernando Bazan: A track record of scientific innovation

8

© 2014 4th & Aspen LLC

Our Services Your Benefits

© 2014 4th & Aspen LLC

9

Preclinical Evaluation Nuanced insights on target disease relevance; predicted effects of target perturbation

Strategic recommendations for small molecule or biotherapeutic design

In vitro/in vivo proof-of-concept strategy recommendations

Opportunity Assessment Integrate molecular/biological and competitive/market frames

Recommend program prioritization to manage risk and increase likelihood of commercial success

Commercialization Support Perform in-licensing scientific diligence

Guide investment/funding/spin-off decisions

Support IP prosecution

Facilitate collaborations with extensive industry & academic network

Marketing & Writing White papers, scientific reviews, grant applications

Presentations that get noticed

Content marketing (blogs, etc.)

© 2014 4th & Aspen LLC

Ready to supercharge your innovation engine?

10

Info[at]4thandaspen.com www.4thandaspen.com 650.996.9927