Post on 06-Apr-2018
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IMMUNOLOGI(MLTHSC1042)Nilaian : 2 Jam kredit
Penilaian berterusan : 40%(Mid sem & Assigment)
Peperiksaan akhir : 60%
Oleh:
Wan Norfaisal Amri b. Wan Noridan
(Bsc. (Hons.) Biomedical Science UKM)
Tel: 013-3452970
Lecturer
Medical Lab Technology Department
Science and Technology Islamic College
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INTRO. CELL&ORGAN HOW DISEASE TEST
1. Definition
2. Importanc
e
3. Immunity
type
4. Immunitycharacteris
tic)
Cell1.Agranulocytes
Lymfphocytes
Monocytes
2. Granulocytes Neutrophile
Basophile
Eosinophile
3. Dendritic cell
4. Mast cell
5. Others
Organ
1. Limfoid
primer
Bone
marrow
Thymus
2.Limfoid
sekunder
Lymphatic
Vessel
Lymph
Nodes
1. Antigen
2. Antibody
3. Agglutination
4. Non-specific
immunologic
reaction
First barrier
Scnd barrier
5. Specific
immunologic
reaction
Third barrier
6. Cytokines
1. Hipersen
sitiviti
2. HLA
3. Immunol
ogical
disorder
1. Immun
oesei
2. Immun
openda
flour
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REFERENCE BOOKS
1. A SHORT COURCE IMMUNOLOGY FIFTHEDITION
Author: Richard coico, Geoffrey sunshine, ElBenjamin
2. A SHORT COURCE IMMUNOLOGY SECONDEDITION
Author: Eli Benjamin and friends
3. Others
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PENGENALAN
DEFINISI
KEPENTINGAN
JENIS
CIRI-CIRI
Objektif pembelajaran:1. Memahami definisi
immunologi dari segi
bahasa dan istilah
2. Mengetahui kepentingan
sistem imun
3. Mengetahuijenis-jenis
sistem imun dalam manusia
beserta ciri2 umumnya
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DEFINISI
Immunologi
Immun-pertahanan badanlogi- Pengetahuan/Ilmu/
Definisi:
Bagaimana sistem badan melindungi badandaripada patogen dan bahan-bahan yangmerbahaya
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KEPENTINGAN SISTEM IMUN
Melindungi badan daripada bahan-bahan yang
merbahaya (virus, bakteria, fungi, patogen, parasitdll)
Memusnahkan sel yang tidak normal dalam
badan (sel kanser)
Mencegah daripada berlakunya pemusnahan sel
sendiri (Autoimmune disease)
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Kepentingan pada masa akan datang..
Gabungan bidang immunologi, genetik danbioteknologi menyumbang kpd pemahaman
tentang:-
Jangkitan
Kanser yg melibatka sum-sum tulang dan seldarah
Reaksi allergik
Penyakit autoimmune
Penyakit kekurangan sel2 dlm sistem imun
Penyakit berkaitan dengan immunosuppresion
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JENIS
1) INNATE IMMUNITY
2) ACQUIRED IMMUNITY
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CIRI-CIRI UMUM
1. Tidak spesifik pada antigen tertentu
2. Respon segera dan cepat (minit)
3. Tiada memori
4. Komponen imuniti:
Pertahanan semulajadi (e.g.kulit)
Sel Fagosit
Bahan larut (protein komplemen)
NATURAL IMMUNITY (semulajadi)
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1. Spesifik terhadap antigen tertentu
2. Respon yang lambat(beberapa hari)3. Mempunyai memori
4. Komponen immuniti:
Limfosit Antibody
ACQUIRED IMMUNITY (perolehan)
Contoh:
Chicken
pox
Vaksinasi
rubella
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NATURAL IMMUNITY (semulajadi)
1) Physical barrier (Perlindungan fizikal)
- skin- mucous membrane in respiratory
- hairs in the nasal tract
- lining cells of the intestinal tract
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2) Chemical barrier (perlindungan kimia)
- gastric juice
- saliva (air liur)
- sweat (peluh)
- tears- human milk
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3) Phagocytosis
- phagocyte cells engulf and destroy aninvading organism, cellular debris, toxin and
foreign body..
*phagocytic cells
- Neutrophil and macrophages
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4) Action of natural killer cells
- non-specific, non-phagocytic cells which candamage virus-infected tissue cells..
5) Action of bodys natural microbial flora
(bacteria normally found in certain part of the
body)
6) Influence by genetic factor
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Specific immune reaction against a foreign
antigen (invading organism, harmful cell ortoxic substance)
2 types of reaction
Humoral immune response (humoral)
Cell mediated immune response (sellular)
ACQUIRED IMMUNITY (perolehan)
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Humoral immune response
-Antibody produced by antigen stimulated immune cells(B-lymphocyte)
- Circulate in the blood
- Produce antibody to react specifically against the
specific antigen
Cell-mediated immune response
Immune cells (T-Lymphocyte and macrophages)directly attack intracellular pathogens, tumor cells and
foreign tissue
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Acquired Immunity
Active
Passive
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Active acquired immunity
recognized a foreign antigen
react specifically
destruction
inactivate
record information about it..
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Occurs when:
Naturally when the body exposed to infection
Artificially when a person is stimulated to produceantibodies (immunized or vaccinated against a
particular disease)
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Passive acquired immunity
Antibody that has been formed in another
person/animal are introduced into the body ofa non-immune person (antibody transfer)
Occurs when:
Naturally (from placenta to baby during
pregnancy, breast milk) Artificially (receive antitoxin/gammaglobulin in the
treatment)
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Natural (Non-specific)
Mechanical barrier Chemical barrier
Phagocytosis
Killer cells
Bodys natural microbial
flora Genetic factor
Acquired (Specific)
Pasive Transplacental/breast
milk
Antitoxin/gammaglobulin
Active
Infection
Immunization/vaccination
Kesimpulan
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